In trying to reduce dairy, I recently substituted butter in a cherry-choc oatmeal cookie for margarine (which, like Crisco, also contains solidified partially hydrogenated oil) in a 1:1 ratio. The dough seemed too liquid, but not to be deterred, I baked one cookie - it spread out massively and was oily. I added more flour until the dough was more firm, and baked a second cookie - it baked well.
So I learned that, when substituting, you may need to experiment with the flour until dough consistency is correct.
Then I made the dough into short columns (2.5cm long), froze them, and a few weeks later baked them from frozen. In the oven, the little columns collapsed into beautiful round cookies. The baked texture was crispy on the outside and chewy on the inside. A delightful success. Baking cookies straight from the freezer is a wonderful trick!